Splet01. avg. 2024 · TRAF6, a RING domain E3 ubiquitin ligase, mediates Lys63 (K63)-linked ubiquitination of several target proteins. Notably, Lys63 (K63)-linked ubiquitination of TRAF6 itself is a key regulatory event in the TLR4-mediated activation of transforming growth factor-b-activated kinase (TAK)-1. Splet04. apr. 2024 · The introduction of 37pA-LNP/6877002 inhibits the activities of TRAF6, a downstream intracellular factor of the CD40L-CD40-TRAF6 axis, to decrease the …
positive regulation of traf6-dependent innate immune ... - 豆丁网
Splet26. nov. 2024 · Through interactions with TNF receptor-associated factor 6 (TRAF6), tripartite motif protein 25 (TRIM25) ... The RAW 264.7 macrophage cell line (American Type Culture Collection, Manassas, VI, USA) was maintained in DMEM supplemented with 10% heat-inactivated FCS, 100 U/mL of penicillin and 100 μg/mL of streptomycin. ... Splet17. okt. 2024 · Conditional deletion of TRAF6 in macrophages selectively inhibits M1 polarization. BMDMs derived from wild-type B6 and LysMCreTraf6fl/fl mice were stimulated with LPS and IFN-γ for M1 polarization, or stimulated with IL-4 and IL-13 for M2 polarization. Nonpolarized BMDMs (M0) were used as controls. clothes shops in southwold suffolk
CD40-TRAF6 and Autophagy-Dependant Anti-Microbial Activity in ...
Splet10. avg. 2024 · The CD40-TRAF6 pathway is mostly important in macrophages [21–23], therefore we hypothesized that the CD40 flfl LysM cre mice would show the same phenotype as the CD40-TRAF6 deficient mice. We now learned that only when macrophage CD40-TRAF6 signaling is deficient, DIO is ameliorated [ 9 ], and deficiency of the whole … Splet28. nov. 2014 · M1-M2 polarization of macrophage is a tightly controlled process entailing a set of signaling pathways, transcriptional and posttranscriptional regulatory networks. ... TRAF6, and IKKβ, which finally leads to the activation of nuclear factor kappa B (NF-κB). As a key transcription factor related to macrophage M1 activation, NF-κB regulates ... SpletCD40-TRAF6 Signaling Inhibitor, 6877002; Synonyms: CD40-TRAF6 Signaling Inhibitor, 6877002,3-((2,5-Dimethylphenyl)amino)-1-phenyl-2-propen-1-one, (2 E)-3-((2,5 ... clothes shops in southwold