Tmed10 translocation
WebDec 11, 2024 · TMED2 is a type I membrane protein that contains a transmembrane (TM) domain, a coil-coiled (CC) domain, and a Golgi dynamics (GOLD) domain. The GOLD domain is a β strand-rich domain involved in Golgi dynamics and intracellular protein trafficking ( Carney and Bowen, 2004, Luo et al., 2007, Strating and Martens, 2009 ). WebJan 23, 2024 · TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation. Naoko Nakano From the Laboratory of Biochemistry, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. Search articles by 'Naoko Nakano' Nakano N1, Yuki Tsuchiya
Tmed10 translocation
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WebJun 27, 2024 · It has been suggested that HSP90A then unfolds IL-1β to expose a signal motif allowing direct translocations into the ERGIC through transmembrane Emp24 domain-containing protein 10 (TMED10) (Figure 3C). Of note, the import of IL-1β by TMED10 is also aided by HSP90B1, although HSP90B1 mechanistic contributions are less well understood . WebMar 10, 2024 · Here, we identified a novel negative regulator of TGF-β signaling, transmembrane p24-trafficking protein 10 (TMED10). TMED10 disrupts the complex …
WebJul 29, 2024 · The TMED10 channel subsequently binds HSP90B1 and translocates the cargo into the lumen of the ERGIC for secretion via a currently undefined mechanism (Fig. …
WebMar 18, 2024 · Go to Variation Viewer for TMED10 variants; Summary. This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. … WebTMED10. IMMUNE CELL CELL LINEAGES. B-CELLS DENDRITIC CELLS GRANULOCYTES MONOCYTES NK-CELLS PROGENITORS T-CELLS TOTAL PBMC. Immune cell proteome. ... Translocation associated membrane protein 1: 0.6303: 47: USO1: USO1 vesicle transport factor: 0.6303: 27: YARS1: Tyrosyl-tRNA synthetase 1: 0.6102: 48: C9orf85:
WebApr 30, 2024 · In the cell, TMED10 localizes on the endoplasmic reticulum (ER)-Golgi intermediate compartment and directs the entry of cargoes into this compartment. …
WebApr 10, 2024 · tmed10介导的蛋白质非经典分泌途径工作模型 在这项研究中，研究人员鉴定出一个膜蛋白TMED10可能形成一个蛋白通道介导UPS蛋白进入囊泡结构。 细胞实验发现，TMED10能够调控大量非经典分泌蛋白的分泌，包括炎症因子IL-1家族成员，galectin1和galectin3，以及小分子 ... hydraulic headstock gear shifterWeb28077 Ensembl ENSG00000133398 ENSMUSG00000021598 UniProt Q9BTT4 Q9CXU0 RefSeq (mRNA) NM_032286 NM_138596 NM_001378925 RefSeq (protein) NP_115662 … massage therapist jobs in boulder coloradoWebMar 10, 2024 · Tmed10 protein, mouse Transforming Growth Factor beta Vesicular Transport Proteins Protein-Serine-Threonine Kinases Receptor, Transforming Growth … hydraulic hiccup fix youtubeWebDec 27, 2024 · TMED10 has an important role in limiting TGF-β signalling. TGF-β is a secreted cytokine that modulates cell proliferation, differentiation and apoptosis, and it is … hydraulic helmWebDec 27, 2024 · Six of the Tmed proteins (Tmed2, Tmed4, Tmed5, Tmed7, Tmed10 and Tmed10-like) are expressed in melanotrope cells, whereas the other two members … hydraulic helm pumpsWebThe interaction of TMED10 C-terminal region with a motif in the cargo accounts for the selective release of the cargoes. In an in vitro reconstitution assay, TMED10 directly mediates the membrane translocation of leaderless cargoes into the liposome, which is dependent on protein unfolding and enhanced by HSP90s. massage therapist jobs craigslistWebJul 29, 2024 · In an in vitro reconstitution assay, TMED10 directly mediates the membrane translocation of leaderless cargoes into the liposome, which is dependent on protein unfolding and enhanced by HSP90s. massage therapist jobs in atlanta