WebASAP3 overexpression counteracts the inhibition of lung adenocarcinoma progression caused by HIF-1α knockdown both in vitro and in vivo. Conclusion: Our results identify ASAP3 as a downstream target of HIF-1α that is critical for metastatic progression in lung adenocarcinoma. Keywords: lung adenocarcinoma, ASAP-3, hypoxia-inducible factor-1α ... Web15 de mar. de 2024 · Background/aims Hypoxia microenvironment plays a crucial role during tumor progression and it tends to exhibit poor prognosis and make resistant to various conventional therapies. HIF-1α acts as an …
Hypoxia-Inducible Factors - an overview ScienceDirect Topics
Web9 de out. de 2007 · VHL binding is dependent upon the hydroxylation of Pro 402 or Pro 564, or both, by the prolyl hydroxylase domain protein 2 (PHD2), which is a dioxygenase that utilizes O 2 and α-ketoglutarate as substrates while generating CO 2 and succinate as by-products (8–13).Under hypoxic conditions PHD2 activity is reduced due to substrate … Web7 de jun. de 2024 · The levels of hydroxy-HIF-1α co-precipitated with VHL were detected using a hydroxy-HIF-1α antibody. b Cellular thermal shift assays to monitor cellular target engagement of VHL and HIF-1α. list of hobbit movies in order of release
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WebASAP3 overexpression counteracts the inhibition of lung adenocarcinoma progression caused by HIF-1α knockdown both in vitro and in vivo. Conclusion: Our results identify … Web11 de abr. de 2024 · HIF-1α directly bound to the promoter of TMEM237 to transactivate its expression. The overexpression of TMEM237 was frequently detected in HCC and associated with poor clinical outcomes in patients. TMEM237 facilitated the proliferation, migration, invasion, and EMT of HCC cells and promoted tumor growth and metastasis in … Web30 de jul. de 2024 · X-ray co-crystal structural analysis revealed that a group of PT compounds selectively bound to the PAS subdomain of HIF-2α not to HIF-1α, resulting in disruption of dimerization with HIF-1β. imarkkeyz never would have made it