Daptomycin and myopathy

Author: gzmu

August undefined, 2024

WebApr 1, 2005 · We conclude that daptomycin was the likely cause of our patient's myopathy and possible hepatotoxicity. To our knowledge, this is the only case of daptomycin myopathy with associated liver function abnormalities. WebDec 28, 2024 · While early studies may have shown daptomycin-associated myopathy rates of 2%–14% and rhabdomyolysis in up to 5% of patients, recently pooled data from large (n = 11 557) patient registries in the United States and Europe report much lower rates of CPK elevation, myalgia, and rhabdomyolysis of 1.5%, 0.2%, and 0.1%, respectively [ 5 ].

Daptomycin Monograph for Professionals - Drugs.com

WebMar 1, 2024 · Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream (bacteremia), … WebSep 1, 2006 · This article will: 1) review the mechanism of myopathy induction by daptomycin; 2) review the literature reports of myopathy associated with … flank shooting

DailyMed - SIMVASTATIN tablet, film coated

WebDaptomycin has excellent coverage against gram-positive bacteria. The adverse effect profile has included rare reports of myopathy and elevated CK levels. Daptomycin is a … WebDaptomycin for Injection is not indicated for the treatment of pneumonia. Daptomycin for Injection is not indicated for the treatment of left-sided infective endocarditis due to . S. … flanks in spanish

Daptomycin 500mg Powder for Solution for Injection/ Infusion

Cubicin (daptomycin) dosing, indications, interactions, adverse …

WebDaptomycin myopathy might be dose or frequency related. In phase 1 trials, two out of five patients developed clinically significant myopathy with myalgias and CK elevation when used at 4 mg/kg/q12 hours . This happened less frequently in further studies using a 4 mg/kg/q24 hours dosage. Of 534 patients in a study receiving daptomycin, only 11 ... WebThere have been reports of myopathy, rhabdomyolysis, and increased creatine phosphokinase (CPK) levels in patients taking daptomycin, which increased when daptomycin was given more than once per day. flank shipWebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal … flanks in hutchinson mn

"WebDec 19, 2024 · Daptomycin has been associated with clinical myopathy in 2% to 14% of patients. Similarly, statins are associated with myopathy in 5% to 10% of patients. … " - Daptomycin and myopathy

Daptomycin and myopathy

Daptomycin Side Effects: Common, Severe, Long Term - Drugs.com

WebDec 11, 2024 · Daptomycin is associated with an increased incidence of myopathy and rhabdomyolysis. There have been cases reported in … WebApr 2, 2024 · Vancomycin (VCM) and daptomycin (DAP) are standard therapies for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, despite concerns regarding clinical utility and growing resistance.

Did you know?

WebDiscontinue with symptoms of myopathy and CPK >1000 U/L (>5x ULN), or no symptoms and CPK >2000 U/L (>10x ULN) CPK elevations more prevalent if dosed more frequently … WebMar 28, 2024 · Daptomycin is a canonical antibiotic used very commonly in practice for its bactericidal activity against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, bone infections, skin and soft tissue infections, meningitis, urinary tract infections, and …

WebDaptomycin is a lipopeptide antibacterial with a spectrum of activity similar to vancomycin but its efficacy against enterococci has not been established. It needs to be given with … WebMar 21, 2024 · Daptomycin was discontinued and the patient was started on treatment for rhabdomyolysis. Despite aggressive hydration and diuresis, CPK and urine myoglobin …

WebJun 6, 2024 · Daptomycin 500mg Powder for Solution for Injection/ Infusion Active Ingredient: daptomycin Company: Panpharma UK Ltd See contact details ATC code: J01XX09 About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) This information is for use by healthcare professionals Last updated … WebMar 10, 2024 · Myopathy, defined as muscle aching or muscle weakness, in conjunction with increased serum CK concentrations up to 10 times ULN reported in patients …

WebNational Center for Biotechnology Information

WebOct 12, 2024 · Atorvastatin, rosuvastatin, and simvastatin all increased the incidence of DAP-related myopathy and rhabdomyolysis. Conclusion: The mixed approach combining a meta-analysis and disproportionality analysis showed that statin use was associated with the occurrence of DAP-related rhabdomyolysis. can rockets shoot through carpetWebOct 10, 2024 · Daptomycin (DAP) is a cyclic lipopeptide antibiotic widely used for patients with methicillin-resistant Staphylococcus aureus infection [1, 2].DAP increases the risk of elevated creatine phosphokinase (CPK) caused by muscle injury, leading to myopathy and rhabdomyolysis in 2%–13% and 5% of the patients, respectively [].Therefore, weekly … can rock break down into sedimentshttp://neuromuscular.wustl.edu/mother/myotox.htm can rocket league run on 4gb ramWebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly. flanks medical termWebDec 28, 2024 · Individually, the incidence of both daptomycin and statin-induced myopathy is rare. While early studies may have shown daptomycin-associated myopathy rates of … flanks in bodyWebJan 28, 2024 · Serious side effects of Daptomycin include: hives , difficult breathing, swelling of the face, lips, tongue, or throat , severe stomach pain, watery or bloody … can rock be carbon datedWebNov 24, 2024 · Daptomycin is a lipopeptide antibiotic that is active against vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). It is less nephrotoxic than vancomycin. … can rock concerts damage hearing