Citron homology cnh domain
WebIn addition to an N-terminal kinase domain and a C-terminal citron homology (CNH) domain, MAP4K3 contains tandem polyproline motifs in its central region (Figure 4.3). The multiple proline-rich domains, which are putative SH3 binding sites, are likely to be involved in protein–protein interaction, and indeed at least one SH3-containing ... Webcarboxy-terminal citron-homology domain (Fig. 1)[10]. MAP4K1 (HPK1) contains a caspase-3 recognition site (Asp-Asp-Val-Asp, amino acids 382 –385) [16]. ... proline-rich motifs in the middle region, and a citron-homology (CNH) domain. The autophosphorylation sites of GLK and HPK1 are phospho-Ser-170 residue and phospho …
Citron homology cnh domain
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WebSep 28, 2024 · a C-terminal citron homology (CNH) domain whose exact function remains unknown, but it has been proposed to interact with either proteins (19, 23 – 25) or lipids, … WebNov 3, 2010 · GCK proteins are characterized by an N-terminal kinase domain and a C-terminal citron homology (CNH) domain separated by a variable region of lower …
WebApr 13, 2024 · Structurally, MAP4K4 comprises several domains, such as an N terminal kinase domain, a coiled-coil domain, a C-terminal hydrophobic leucine-rich citron homology domain (CNH) and two putative caspase cleavage sites [37,39,40,41]. The CNH domain has been shown to be important for protein–protein interactions. WebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology …
WebBased on sequence similarities a domain of homology has been identified in the following proteins [ (PUBMED:10391936) ]: Citron and Citron kinase. These two proteins interact … WebMay 26, 1998 · The process of constructing SMART predicted ( i) novel domain homologues in unexpected locations such as band 4.1-homologous domains in focal adhesion kinases; ( ii) previously unknown domain families, including a citron-homology domain; ( iii) putative functions of domain families after identification of additional family …
WebSTKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily contain an N-terminal catalytic …
WebSep 20, 2024 · The CNH domain plays an essential role as a stabilizer for the small GTPase Rho1, a key regulator of glucan biosynthesis. This work provides a model for their … irish teacher jailed for pronounsWebJan 6, 2024 · C-terminal citron homology (CNH) domain (Delpire 2009). In Caenorhabditis elegans and flies, this family comprises only. one member, namely, MIG-15 and MSN, respectively. They. irish tea vs english teaWebidentified a citron homology (CNH) domain (residues 142 , 274;Figure2B)attheN-terminalandaclathrin heavy-chain repeat homology (CLH) domain (residues 623 , 757) at C-terminal (Figure 1). The CNH port for home theaterWebCitron homology (CNH) domain Citron Rho-interacting kinase PH-like domain superfamily Pleckstrin homology domain Protein kinase, ATP binding site Protein … port for mapping network driveWebOct 14, 2024 · The CNH domain is present near the C-terminus of the Sticky/Citron kinase of flies, a RhoA-interacting kinase required for the organisation of the midbody in late cytokinesis [ 44] and in other kinases, such as the NIK (nck-interacting kinase) [ 45 ]. irish teacher murderedWebNov 19, 2004 · The CNH domain of GCK-I subfamily members are only distantly related to those of GCK-IV subfamily members (less than 20% amino acid identity). On the other … port for lymphomaWebApr 16, 2004 · The CNH domain was originally found in citron that interacts with Rho and Rac . Subsequently, it was found in Rom2p, a GDP/GTP exchange factor for S. … irish teaching council registration